News & Events
News & Events

Publications

General Articles

Better World Report Cover
  1. Wall Street Transcript, November 5, 2007
  2. Medscape Medical News, April 2007 Novel Rho Inhibitor Safe, May Improve Recovery After Spinal Cord Injury
    Preliminary clinical data suggest that a novel Rho inhibitor, applied during spinal decompression and stabilization surgery, is safe and feasible and may improve neurological outcomes after acute spinal cord injury. A randomized trial is planned.
  3. The Association of University Technology Manager's (AUTM) "The Better World Report" included the ALTROPANE® molecular imaging agent in its 2006 edition entitled "Technology Transfer Stories: 25 Innovations That Changed the World."

    To view or download a PDF copy click here.

Scientific Articles

Molecular Imaging

  1. Fernandez, HH, MD, Ravin PD, MD, and Wint, DP, MD, [123I] Altropane SPECT How It Compares to Other Positron Emission Tomography and Single Photon Emission Tomography Dopamine Transporters in Early Parkinson's Disease. BIOIMAGING IN NEURODEGENERATION Chapter 4, 2005:37-44.
  2. Madras BK, Meltzer PC, Liang AY, Elmaleh DR, Babich J, Fischman AJ. Altropane, a SPECT or PET Imaging Probe for Dopamine Neurons: I. Dopamine Transporter Binding in Primate Brain. Synapse 1998: 29:93-104.
  3. Madras BK, Lawrence MG, Meltzer PC, Liang AY, Elmaleh DR, Kaufman MJ, Fischman AJ. Altropane, a SPECT or PET Imaging Probe for Dopamine Neurons: II. Distribution to Dopamine-Rich Regions of Primate Brain. Synapse 1998: 29:105-115
  4. Madras, BK, Gracz LM, Fahey MA, Elmaleh D, Meltzer PC, Liang AY, Stopa EG, Babich J, Fischman AJ. Altropane, a SPECT or PET Imaging Probe for Dopamine Neurons: III. Human Dopamine Transporter in Postmortem Normal and Parkinson's Diseased Brain. Synapse 1998;29:116-127
  5. Fischman AH, Bonab AA, Babich JW, Palmer EP, Aplert NM, Elmaleh DR, Callahan RJ, Barrow SA, Graham W, Meltzer PC, Hanson RN, Madras BK. Rapid Detection of Parkinson's Disease by SPECT With Altropane: A Selective Ligand for Dopamine Transporters. Synapse 1998;29:128-141.
  6. Dougherty D, Bonab A, Spencer T, Rauch S, Madras B, Fischman A. Dopamine transporter density in patients with attention deficit hyperactivity disorder. The Lancet December 18/25 1999; Vol 354
  7. Spencer, T., Biederman, J., Madras, B.K., Dougherty, D.D., Bonab,A.A., Livni, E., Meltzer, P.C., Martin,J., Rauch, S., and Fischman, A.J., Further Evidence of Dopamine Transporter Dysregulation in ADHD: A Controlled PET Imaging Study Using Altropane. Biological Psychiatry Volume 62, Issue 9, 1 November 2007, Pages 1059-1061.

Nerve Repair

  1. Benowitz LI, Jing Y, Tabibiazar R, Jo SA, Petrausch B, Stuermer CAO, Rosenberg PA, Irwin N. Axon Outgrowth Is Regulated by an Intracellular Purine-sensitive Mechanism in Retinal Ganglion Cells. The Journal of Biological Chemistry 1998; Vol 273, No. 45, Issue of November 6, pp. 29626-29634.
  2. Li Y, Irwin N, Yin Y, Lanser M, Benowitz LI. Axon Regeneration in Goldfish and Rat Retinal Ganglion Cells: Differential Responsiveness to Carbohydrates and cAMP. The Journal of Neuroscience, August 27, 2003; 23(21):7830-7838
  3. Fischer D, He Z, Benowitz LI. Counteracting the Nogo Receptor Enhances Optic Nerve Regeneration If Retinal Ganglion Cells Are in an Active Growth State. The Journal of Neuroscience, February 18, 2004; 24(7)1646-1651
  4. Benowitz LI, Goldberg DE, Madsen JR, Soni D, Irwin N. Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proceedings of the National Academy of Sciences, November 9, 1999; Vol. 96, No. 23, 13486-13490.
  5. Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI. Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve. The Journal of Neuroscience, June 15, 2000; 20(12):4615-4626.
  6. Yin Y, Cui Q, Irwin N, Fischer D, Harvey AR, Benowitz LI. Macrophage-Derived Factors Stimulate Optic Nerve Regeneration. The Journal of Neuroscience, March 15, 2003; 23(6):2284-2293.
  7. Petrausch B, Tabibiazar R, Roser T, Jing Y, Goldman D, Stuermer CAO, Irwin N, Benowitz LI. A Purine-Sensitive Pathway Regulates Multiple Genes Involved in Axon Regeneration in Goldfish Retinal Ganglion Cells. The Journal of Neuroscience, November 1, 2000; 20(21):8031-8041.
  8. Fischer D, Petkova V, Thanos S, Benowitz LI. Switching Mature Retinal Ganglion Cells to a Robust Growth State In Vivo: Gene Expression and Synergy with RhoA Inactivation. The Journal of Neuroscience, October 20, 2004; 24(42).
  9. Peng C, Goldberg D, Kolb B, Lanser M, Benowtiz L. Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proceedings of the National Academy of Sciences, June 25, 2002; Vol. 99, No. 13, 9031-9036.
  10. Sivasankaran R, Pei J, Wang K, Zhang Y, Shields C, Xiao-Ming X, He Z. PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nature Neuroscience, March 2004; Vol. 7, No. 3, 261-268.
  11. Wang K, Koprivica V, Kim J, Sivasankaran R, Guo Y, Neve R, He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. June 27, 2002; Vol 417, 941-944
  12. Park J, Yiu G, Kaneko S, Wang J, Chang J, He Z. A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors. Neuron. February 3, 2005; Vol. 45, 345-351.
  13. Koprivica V, Cho K, Park J, Yiu G, Atwal J, Gore B, Kim J, Lin E, Tessier-Lavigne M, Chen D, He Z. EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans. Science Magazine. October 7, 2005; Vol. 310, 106-110.
  14. Wang K, Kim J, Sivasankaran R, Segal R, He Z. p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. November 7, 2002; Vol 420, 74-78.
  15. Yuqin Y, Henzl M, Lorber B, Nakazawa T, Thomas T, Jiang F, Langer R, Benowitz L. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nature Neuroscience. May 14, 2006;
  16. Dergham P, Ellezam B, Essagian C, Avedissian H, Lubell W, McKerracher L. Rho Signaling Pathway Targeted to Promote Spinal Cord Repair;The Journal of Neuroscience. August 1, 2002; 22 (15):6570–6577.
  17. Dubreuil C, Winton M, McKerracher L. Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system; The Journal of Cell Biology. July 21, 2003; Volume 162, Number 2, 233–243.
  18. Ellezam B, Dubreuil C, Winton M, Loy L, Dergham P, Sellés-Navarro I, McKerracher L. Inactivation of intracellular Rho to stimulate axon growth and regeneration; Progress in Brain Research. Vol. 137.

Dopamine Transporters

  1. Uhl G, Lin Z. The top 20 dopamine transporter mutants: structure-function relationships and cocaine actions. European Journal of Pharmacology. August 21, 2003; Vol 479, 71-82.
  2. Uhl G. Dopamine Transporter: Basic Science and Human Variation of a Key Molecule for Dopaminergic Function, Locomotion, and Parkinsonism. Movement Disorders. 2003; Vol 18, pp. S71-S80.
  3. Bannon M, Michelhaugh S, Wang J, Sacchetti P. The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders. European Neuropsychopharmacology. 2001; Vol 11, 449-455.
  4. Bannon M. The dopamine transporter: role in neurotoxiity and human disease. Toxicology and Applied Pharmacology. October 24, 2004; Vol 204, 355-360.
  5. Nutt J, Carter J, Sexton G. The Dopamine Transporter: Importance in Parkinson's Disease. Annals of Neurology. June 2004; Vol 55, No 6, pp 766-773.
  6. Madras B, Fahey M, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer P, Elmaleh D, Livni E, Bonab A, Fischman A. Dopamine Transporter (DAT) Inhibitors Alleviate Specific Parkinsonian Deficits in Monkeys: Association With DAT Occupancy In Vivo. American Society of Pharmacology and Experimental Therapeutics 2006; DOI:10.1124/jpet.106.105312